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Depending on the study type these third Tier studies are often critical in the timeline to submission. Beside this second Tier study there might even be a third Tier study which is then even more complex, time consuming and more expensive. Higher Tier in this context means a study which is closer to nature/reality and is more complex and consequently more time consuming and expensive. If the outcome cannot demonstrate the necessary safety of the compound a higher Tier study needs to be conducted. It means that the first study might be a relatively simple, fast and cheap but also very conservative study (usually laboratory studies). The results of the higher Tier study overrule those of the simpler study because the higher tier studies are set up to be closer to nature/reality and therefore more relevant.Īs studies to elucidate the behavior of a plant protection compound might be very time consuming and expensive the necessary information is partly derived via a tiered approach. Besides this second tier study, there might even be a third Tier study which is then even more complex, time-consuming, and more expensive. Higher Tier in this context means a study that is closer to nature/reality and is more complex and consequently more time-consuming and expensive. It means that the first study might be a relatively simple, fast, and cheap but also very conservative study (usually laboratory studies). As studies to elucidate the behavior of a plant protection compound might be very time-consuming and expensive the necessary information is partly derived via a tiered approach.